Press Release And Interview


New universal adhesive with active moisture control

Dentsply Sirona is proud to introduce Prime&Bond universal™ universal adhesive. Designed for all etching methods and indications, Prime&Bond universal features patented Active-Guard™ Technology – a significant advancement in adhesive chemistry that actively controls moisture on the prepared surface. Even if dentin is overly wet or dry, Prime&Bond universal is simple to use and provides consistent results for a strong, reliable bond.

Most dental adhesives are rather hydrophobic: they separate from water. With too much water on the prepared surface, these rather hydrophobic adhesives fail to cover the prepared surface uniformly. During air-drying, adhesive gaps can form as embedded pockets of water evaporate, increasing the risks of post-operative sensitivity and bond failure.

Active-Guard Technology with active moisture control is exclusively designed to protect against these risks.

The patented Active-Guard Technology balances hydrophobic and hydrophilic features and helps to achieve an optimized surface tension. Thus, Prime&Bond universal can overcome the surface tension of water, allowing the adhesive to spread evenly across the dentin and into the dentinal tubules to form a uniform, homogeneous layer. When the adhesive is air-dried, solvent and excess water evaporate uniformly to leave a thin, consistent coating of adhesive across the entire surface. The result is a strong, reliable bond, with virtually no post-operative sensitivityi.

In addition to active moisture control, Prime&Bond universal provides several benefits over competing universal adhesives, including:

Active spreading across the prepared surface to minimize the risk of dry spots that can lead to post-operative sensitivity and micro-leakage.

Low film thicknessii, minimizing the risks of changing the preparation geometry and compromising crown fit, or leaving adhesive pools that may show up on radiographs and can be misdiagnosed a voids, gaps or secondary decay.

No need to apply an activator when used with Calibra® Ceram cement.

Convenience and control, with one-handed opening of Flip Top Cap bottle, precise dispensing and up to 30 minutes of working time in a closed CliXdish™.

Innovative formulation without any HEMA, TGDMA and Bisphenol.

Prime&Bond universal with patented Active-Guard technology is simple to use, delivers consistent results and helps ensure a strong bond even when dentin is overly wet or dry. To learn more and try a sample, contact your Dentsply Sirona representative or visit www.dentsply.eu.


i Data on file.
ii “Film Thickness study”, Andre F. Reis, DDS, MS, PhD.
Press Contact

Verena Schuetter
Marketing Communication Manager, Asia Regional Marketing

DENTSPLY SIRONA Inc. (Hong Kong Branch)
29/F Excel Centre
No. 483A Castle Peak Road
Cheung Sha Wan, Hong Kong

Dir Line: +852 2871 5192
Mobile: +852 9330 2366
Fax: +852 2870 0620
verena.schuetter@densplysirona.com


ABOUT DENSPLY SIRONA: Dentsply Sirona is the world's largest manufacturer of professional dental products and technologies, with a 130-year history of innovation and service to the dental industry and patients worldwide. Dentsply Sirona develops, manufactures, and markets a comprehensive solutions offering including dental and oral health products as well as other consumable medical devices under a strong portfolio of world class brands. As The Dental Solutions Company™, Densply Sirona's products provide innovative, high-quality and effective solutions to advance patient care and deliver better, safer and faster dentistry. Dentsply Sirona's global headquarters is located in York, Pennsylvania, and the international headquarters is based in Salzburg, Austria. The company's shares are listed in the United States on NASDAQ under the symbol XRAY. Visit www.dentsplysirona.com for more details.

“This is a game-changer”: Prime&Bond universal™ with Active-Guard™ Technology
Dentsply Sirona has introduced a new universal adhesive designed to ensure complete coverage and penetration for a reliable bond even if the preparation is overly wet or dry.
We spoke with Dentsply Sirona polymer chemist Dr. Christoph P. Fik to learn about the remarkable properties of this revolutionary dental adhesive and how Prime&Bond universal™ with Active-Guard™ Technology was developed.
Dr. Fik, can you tell us how a new research and development effort gets started? For example, did the marketing team develop a list of requirements that dentists are looking for in a next-generation adhesive like Prime&Bond universal™?

The marketing people do conduct market research and develop a set of requirements based on the voice of customers. As chemists, we also have our own insights into the physical and chemical properties that would improve the product and simplify its use for our dental customers. The clinical team also provides significant input, so it’s a collaboration between all three departments to define the platform requirements for a new product.

We have a series of discussions, document our agreed-upon objectives, and then kick off the actual development effort with a clear set of goals in sight that we believe are both beneficial and achievable.

Talk to us about those goals. What does the ideal dental adhesive need to accomplish?

I see the dentist as a kind of craftsman, and we want to help them achieve a higher level of craftsmanship. Every dentist has preferred techniques to achieve a good restoration for every case, and we’re not necessarily changing that. We want to help enhance craftsmanship with a universal adhesive that dentists can rely on, a product that makes a difference they can see and feel every day they work with it.

Dentists want a universal adhesive that’s more convenient, easier and faster, while ensuring a reliable bond. It needs to provide robust performance across all the different cases a dentist encounters, including direct and indirect restorations. It needs to be simple and predictable to use in every scenario.

What are the limitations of competing adhesives, and how does Prime&Bond universal™ overcome them?

There are six or seven universal adhesives on the market based on chemistry that’s at least 20 years old. Most of these established adhesives have very high viscosity. Some dentists may regard that as a benefit in certain cases, but more often it’s a significant drawback. Prime&Bond universal™ is the first universal adhesive that offers low viscosity with a surface tension directly adjusted to dental substrates and related materials, making it easier for the adhesive to spread evenly across the substrate and to quickly wet and fully penetrate the dental tubules.

Other universal adhesives show what I would describe as a passive behavior. They polymerize, but beyond that they don’t exhibit any active properties to help the dentist achieve optimum results. They can resist spreading, they tend to pool, and they don’t mix with water spontaneously – so it can be difficult to achieve complete, even coverage.

By contrast, the “active” in Prime&Bond universal™ with Active-Guard™ Technology refers to the properties you can actually see working when you apply it to the prepared surface. It actively spreads to help ensure complete and uniform coverage across the substrate. It actively mixes with any excess water that may be present, which is important for achieving complete penetration on wet dentin. During air drying, the adhesive solvent and excess water evaporate together to actively create an even, homogenous layer with low film thickness.

The active properties you’re describing are completely new in the market for universal adhesives. Active-Guard™ Technology is patented. What is it and how does it work?

Active-Guard™ Technology is a resin component. Other universal adhesive systems are based on two parts: They combine a very hydrophilic, low viscosity compound – a so-called reactive diluent – with a very viscous hydrophobic compound, trying to find a balance. With Active-Guard™ Technology, we’ve created a new resin compound that combines hydrophobic and hydrophilic properties in one monomer. So you don’t have to deal with two parts and reactive diluents – you simply find the balance within a single chemical structure.

Could it be described as “amphiphilic.”? Is that what you mean by a balance of hydrophobic and hydrophilic within a single resin molecule?

Yes, but it’s important to distinguish the amphiphilia of Active-Guard™ Technology from the more familiar use of this term to describe surfactants. With those, you have separate hydrophilic and hydrophobic parts in one molecule, and that’s what allows you to disperse oil in water, for example. But with Prime&Bond universal™, the whole molecule in itself balances hydrophobic and hydrophilic properties, without separate hydrophobic and hydrophilic domains of the molecule.

That’s unusual in chemistry, and it allows us to balance several benefits. For example, enamel is hard, dry and quite brittle, while dentin is porous, wet and spongy, and the amphiphilicity of Active-Guard™ Technology allows us to achieve exceptional bond strength with both substrates. We’ve also achieved an optimum balance between the properties needed for direct and indirect restorations, between high and low viscosity, and between the requirements for all etching methods.

What are some of the additional benefits of Prime&Bond universal™?

The adhesive layer is extremely thin compared to other universal adhesives, which can really help avoid fitting problems with indirect restorations. This thinness, combined with a mild pH of about 2.5, also practically eliminates the most common causes of post-operative sensitivity. And it minimizes the risk of pooling, which can otherwise be misinterpreted as a void or decay on a radiograph.

We also thought about simplifying the dentist’s workflow. Prime&Bond universal™ can be stored at room temperature and remains usable for 30 minutes in a closed CliXdish, so it’s really designed to minimize waste and help streamline procedures, especially when doing multiple restorations in a single visit.

And we make sure our products work together, so dentists can have a complete and reliable solution with no risk of product incompatibilities. We designed Prime&Bond universal™ to work optimally with Calibra® Ceram cement. With this combination, there’s no need to apply a separate activator, and the two products have the right pH values to fuse perfectly, providing much greater shear bond strength compared to other adhesives.



In all you have accomplished to develop Prime&Bond universal™, what gives you the most pride? How will this change the practice of dentistry?

Our patented Active-Guard™ Technology platform is completely new. It introduces a new level of robustness along with much simpler, more reliable handling properties for virtually any case, any substrate and any preparation. It’s a future-oriented technology that I’m convinced will lead to more groundbreaking products based on this platform in the future. I’m very proud of that. It’s a game-changer.


Manufacturer Contract Information
 • Website: www.dentsply.eu
 • Address: De-Trey-Straße 1, 78467 Konstanz, Germany
 • Phone Number: +49-7531-583-0
 • Email: info@dentsply.de
“It’s truly unique”: Prime&Bond universal™ with Active-Guard™ Technology
Dentsply Sirona has introduced a new universal adhesive that simplifies restorations and provides a reliable bond under the most challenging conditions. We spoke with Dr. Rainer Seemann, Director of Clinical Affairs at Dentsply Sirona, to learn how new dental products are created, and how Prime&Bond universal™ with Active-Guard™ Technology will change the practice of restorative dentistry.
Dr. Seemann, how would you describe the function of the Clinical Affairs team in the process of developing a new product?

Our role is to provide clinical insights that help define what a new product should offer to dentists. The process begins with a blank slate as we work to discover unmet user needs. What should the new product do? How should it behave? What benefits should it offer? Once we have created a wish list, the R&D team comes into play and translates our user requirements into material properties that can be quantified. But first, we need to define what we’re trying to achieve.

Dentists are accustomed to the products they’re already using. How do you go about discovering their unmet needs, so you can define new product capabilities that may never have existed before?

We get input from dentists from around the world. We ask for their feedback on our initial ideas, and we also get them talking about their own needs and wishes – which often leads to ideas we hadn’t thought about before. These inputs range from very informal to highly structured.

There are about eight dentists on our team, and we’re always talking with them informally to come up with ideas for a better product. We also have formal focus groups where we bring in dentists to learn how they work and explore their aspirations for improving their practice. And we spend a lot of time out in the field, visiting dental conferences and shows, talking to dentists wherever we can.

Another very structured method for discovering unmet needs is through our interactions with key opinion leaders in the dental industry. We put our ideas in front of them, or present actual prototypes, and we ask them whether this is something that dentists might need.

In all these interactions, it’s important to bring the right people together, ask the right questions, and be fully receptive to what dentists and opinion leaders have to say. You can’t create a breakthrough product by following conventional wisdom. You need to build collaborative relationships focused on discovering new possibilities.

Beyond the process of discovering clinical needs, are there other predevelopment research activities go into a project like Prime&Bond universal™?

From the Clinical Affairs side, we’re focused on learning what dentists ideally want. But we also need to look at what’s possible to deliver, and that’s Research & Development’s role. They have the expertise in chemistry. The R&D team often partners with outside experts to develop new technologies that can advance the capabilities of dentistry. For example, R&D works with research universities to develop new monomers, new technologies that go into our products.

Prime&Bond universal™ is Dentsply Sirona’s latest entry in the growing category of universal adhesives. What drives the decision to use self-etch, selective-etch or total-etch techniques?

When I was a young dentist, there were no products that could bond to dentin, so we were simply etching enamel and trying to get a good bond that way without touching the dentin at all. Later, total-etch products became available that bonded to enamel and dentin, but you still had to etch with phosphoric acid and rinse before applying the adhesive.

The next step was self-etch adhesives, which combine mild etching properties bonding in the same monomer. Self-etch adhesives eliminate the separate etching step and reduce the risk of post-operative sensitivity from using harsh phosphoric acid.

Self-etch and total-etch products both have their strengths. You might choose total-etch to get a strong bond when there’s a lot of enamel present, but you might use self-etch when there’s more dentin or when you’re working with a difficult posterior preparation. Or, when you have a fussy child in the chair and need to get the job done quickly.

With total-etch and self-etch, dentists needed to purchase multiple products to handle different cases. But today’s universal adhesives allow you to total-etch or self-etch using the same adhesive. Universal adhesives also offer a new possibility, the selective-etch method. You can selectively etch the enamel to get the strongest bond and still benefit from a universal adhesive’s self-etching property to bond to dentin.

So universal adhesives are already a big step forward for convenience and versatility. What does Prime&Bond universal™ add to the category?

You’ll notice we didn’t call it Prime&Bond “universal.” It is a universal adhesive, true, but it’s unique within that category and that’s why we call it “active.” Our patented Active-Guard™ Technology actively addresses a variety of challenges for different restoration types and cases.

First is the ability to control moisture. Dentin is living tissue, and living tissue is always wet to some degree. Other universal adhesives are relatively hydrophobic. If the preparation is too wet, they have difficulty penetrating the moisture in the collagen fiber network and tubules. But if the preparation is overly dried, the collagen network collapses. Either way, you don’t get the bond strength you want, and you can get gaps that lead to post-operative sensitivity or even secondary caries at later stage.

Active-Guard™ Technology provides crosslinkers with an optimum balance of hydrophobic and hydrophilic properties in the same monomer. Prime&Bond universal™ is the only universal adhesive that actively manages moisture. If the preparation is too wet or overly dried, it still gets into the collagen fibers and tubules to create a strong, reliable bond. There’s much less concern over whether the preparation is just right in terms of moisture.

That does sound incredibly useful. Anything else?

Yes. This same molecular innovation also helps to optimize surface tension, allowing Prime&Bond universal™ to spread actively across the substrate and form a thin, even layer of adhesive. You can actually see it working. Other universal adhesives just sit there – or worse, they separate from any excess water that may be present.

So what you have when you use Prime&Bond universal™ is a universal adhesive that works with your preferred etching technique, spreads easily to form a homogeneous layer, and creates a strong and reliable bond even if the surface preparation isn’t at the ideal moisture level. It creates an extremely thin and even bond, so indirect restorations fit properly.

We also designed it to work with Calibra® Ceram cement for optimum bond strength, with no need to apply an activator. And in all our tests, involving several thousand restorations, we found virtually no occurrence of post-operative sensitivity. Plus, it remains usable for up to 30 minutes in a closed CliXdish, so you can do multiple restorations efficiently with minimal waste.


In other words, for convenience, ease of handling, versatility and reliability under practically any clinical conditions, there’s never been a dental adhesive like Prime&Bond universal™. It’s truly unique, and I’m excited to be part of that.


Manufacturer Contract Information
 • Website: www.dentsply.eu
 • Address: De-Trey-Straße 1, 78467 Konstanz, Germany
 • Phone Number: +49-7531-583-0
 • Email: info@dentsply.de

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©2018 Dentsply Sirona. All rights reserved. Terms of use Privacy Policy